COMPUTATIONAL PREDICTION OF VACCINE POTENTIAL EPITOPES AND 3-DIMENSIONAL STRUCTURE OF XAGE-1B FOR NON-SMALL CELL LUNG CANCER IMMUNOTHERAPY

Computational prediction of vaccine potential epitopes and 3-dimensional structure of XAGE-1b for non-small cell lung cancer immunotherapy

Background: XAGE-1b is shown to be overexpressed in lung adenocarcinoma and to be a strong immunogenic antigen among non-small cell lung cancer (NSCLC) patients.However, 3D structure of XAGE-1b is not available and its confirmation has not been solved yet.Methods: Multiple sequence alignment was run to select the most reliable templates.Homology mo

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Machine learning for the rElapse risk eValuation in acute biliary pancreatitis: The deep learning MINERVA study protocol

Abstract Background Mild acute biliary pancreatitis (MABP) presents significant clinical and economic challenges due to its potential for relapse.Current guidelines advocate for early cholecystectomy (EC) during the same hospital admission to prevent recurrent acute pancreatitis (RAP).Despite these recommendations, implementation in clinical practi

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Tensile simulation of 6061 aluminum alloy

The quasi-static tensile simulation was carried out on the 6061 aluminum alloy round bar specimen, and the tensile specimen model was drawn.Three sets of simulation with uniaxial tensile velocity of 10 s-1, 15 s-1 and 20 s-1 Heating Rods were set at normal temperature, and the numerical simulation of the tensile process was carried out by using ABA

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Monarchy and Universities in the Hispanic kingdoms (13th-15th centuries): interventionism in their government and funding

This paper studies the differences between the Crowns of Castile and Aragon in the relationship between monarchy and universities in the Late Middle Ages.In the case of the first Castilian universities, it nuances the excessive importance that historiography has granted to the monarchs in their foundation and instead stresses that the initiative ca

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